The TRIC refers to "tRNA in cancers". Transfer RNAs (tRNAs) play essential roles in tumorigenesis. The database tRNA in Cancer (TRIC) show the dynamic landscape of tRNAs expression across 31 cancer types and more than 10000 samples from The Cancer Genome Atlas (TCGA). Here we systematically analyzed tRNA expression profiles at gene, codon and amino acid levels and the functional consequence (e.g. patient tumor stage, subtype, and survival). We also try to connect the differentially expression of tRNA and the translational control in tumor.
tRic has been published at:
Zhang, Z., Ruan, H., Liu CJ. et al. tRic: a user-friendly data portal to explore the expression landscape of tRNAs in human cancers. RNA Biology (2019) doi: 10.1038/s42003-018-0239-8
Please also cite:
Zhang, Z., Ye, Y., Gong, J. et al. Global analysis of tRNA and translation factor expression reveals a dynamic landscape of translational regulation in human cancers. Commun Biol 1, 234 (2018) doi: 10.1080/15476286.2019.1657744